development and validation of rp-hplc method for simultaneous estimation of rosuvastatin calcium and fenofibrate in bulk and pharmaceutical dosage forms. However, no HPLC method for the simultaneous estimation of atorvastatin calcium and fenofibrate in combined dosage forms has been reported so far 12. The present work describes the development of simple, precise and accurate isocratic reverse phase HPLC method for simultaneous estimation of AC and FB in tablets. METHOD DEVELOPMENT AND VALIDATION OF FENOFIBRATE BY HPLC USING HUMAN PLASMA M.T. Zzaman 1, S.A. Khan 2, A. Arora 1, O. Ahmad 2 1 KIET School of Pharmacy, Ghaziabad. Fenofibrate is a synthetic Peroxisome Proliferator Receptor alpha (PPAR alpha) Agonist as well as a antilipemic agent. It is used to help lower bad cholesterol and fats (LDL, triglycerides) by increasing the natural enzyme that breaks down fats in the blood. development and validation of rp-hplc method for the estimation of choline fenofibrate in bulk and its pharmaceutical dosage form html full text Fenofibrate is an antihyperlipidemic agent. Structures for fenofibrate (I) and several related compounds are provided in Fig. 1. Compounds I–XII and XVIII were available for method development. Development and validation of HPLC-UV method for the estimation of fenofibrate in human plasma The objectives of the study were to develop a rapid, simple, and economical HPLC method for the estimation of Fenofibrate in plasma and to validate the developed bioanalytical method. 134 FENOFIBRATE Bioanalytical method development and Validation using HPLC 5.1 DRUG PROFILE Fenofibrate Fenofibrate is an antilipidemic agent which reduces both cholesterol and The developed method can be used for routine quality analysis of titled drugs in combination in tablet formulation. Key words: Rosuvastatin, Fenofibrate, RP-HPLC, validation, simultaneous estimation.